Bone Marrow Voyage by Gomariz Alvaro, University Hospital of Zurich
Entry in category 4. ©Alvaro Gomariz; See also bit.ly/snsf_comp_copy
An immunostained sample of bone marrow in mice was acquired in 3D confocal microscopy with 20x magnification. A maximum intensity projection of this 3D image is shown here. The green signal corresponds to GFP-CXCL12 signal, which is mainly expressed by some reticular mesenchymal cells. These cells were automatically detected by a computer algorithm and are represented as pink spheres. Immunostained blood vessels were also detected and are represented in red in the video. The white surface corresponds to the bone surface which surrounds the bone marrow, as detected by a different custom-designed algorithm. Data was acquired on 14-11-16, and the computational reconstruction was performed on 10-02-17.
Interior cavity of a bone as seen by 3D microscopy techniques combined with advanced computational methods. This combination allows the observation of the cellular population (pink), and how they intermingle with the blood vessels (red), together forming a fascinating network inside our bones. With these representation methods we can gain insight into the microarchitecture of the bone marrow and the nature of the blood cell production. ¦ Image#4_16
Bone Marrow Voyage by Gomariz Alvaro, University Hospital of Zurich
Entry in category 4. ©Alvaro Gomariz; See also bit.ly/snsf_comp_copy
An immunostained sample of bone marrow in mice was acquired in 3D confocal microscopy with 20x magnification. A maximum intensity projection of this 3D image is shown here. The green signal corresponds to GFP-CXCL12 signal, which is mainly expressed by some reticular mesenchymal cells. These cells were automatically detected by a computer algorithm and are represented as pink spheres. Immunostained blood vessels were also detected and are represented in red in the video. The white surface corresponds to the bone surface which surrounds the bone marrow, as detected by a different custom-designed algorithm. Data was acquired on 14-11-16, and the computational reconstruction was performed on 10-02-17.
Interior cavity of a bone as seen by 3D microscopy techniques combined with advanced computational methods. This combination allows the observation of the cellular population (pink), and how they intermingle with the blood vessels (red), together forming a fascinating network inside our bones. With these representation methods we can gain insight into the microarchitecture of the bone marrow and the nature of the blood cell production. ¦ Image#4_16